In fact, it is pivotal the development, use, and management of the best and most suitable coatings to be supplied to vessels—especially those designed for long journeys; not only to increase their stability and safety but also to minimize their maintenance cost. In this regard, it should be also considering the function, the vessel typology and its routes, as well as the quality of the waters by which it will navigate. Topics that are critical to promote a better dimensioning process of vessels. Thus, the present chapter, via an extensive literature review articulated with practical approaches, aims to define relevant directions for vessels structural development processes regarding the water quality (sea or river waters), where they will outline their routes. Therefore, the study looks for a relationship between the vessels structural coating design process and the quality of the water where they navigate. Moreover, such a process not only will optimize/minimize the costs with the periodic maintenance of the vessels linings, but also to relate it with its routes—contributing to the revitalization of their structural dimensioning.